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pentobarbital will decrease the level or impact of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the level or effect of capivasertib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Potent or average CYP3A inducers lessen capivasertib exposure, which may reduce ef